The system and user settings include all settings in the Options dialog box under File Positions, System Options, and User Preferences, such as the user interface color settings and the Auto Save preferences.
This also includes the language setting for the program. The language setting corresponds to the operating system settings by default but can be changed to English or another available language at any time. A restart of the program is necessary for the conversion.
Options > General > Application language
For many users it is important to set the direction of the mouse wheel:
Options > User preferences > Mouse options > Reverse the direction of the mouse wheel.